Perimenopause 101: What It Is and How to Treat Its Many Symptoms
“Our moms never talked about this; I can only remember my mom complaining about hot flashes,” says Kimberlee Coleman, MD, a board-certified ob-gyn at Pediatrix Medical Group in Margate, Florida, recalling how much has changed, even since she was in medical school 25 years ago.
The undefined nature of what is and isn’t a perimenopause symptom, combined with the fact that it’s only recently become a popular subject, has made getting treatment frustrating for many patients. But luckily for us, we’re in a kind of golden age of perimenopause research, where there’s now a plethora of online perimenopause prescription services available. “Our generation, we’re not going to suffer through it. We’re more verbal, more independent, more educated. And so we are going to push for some type of treatment,” says Dr. Coleman.
What Are the Symptoms of Perimenopause?
Here are some of the most common perimenopause symptoms:
- Abnormal periods (irregular, heavy bleeding, etc.)
- Mood swings
- Sleep problems
- Night sweats
- Hot flashes
- Vaginal dryness
- Lower libido
- Weight gain
- Urinary tract infections
- Increased need to urinate
- Memory problems/brain fog
- Thinning hair
- Dry skin
- Headaches
One of the things that has surprised Coleman the most in her practice is how varied everyone’s symptoms are. The same has been true in her personal experience. “One of my best friends — her thing is insomnia,” she says. “My other girlfriend has vaginal dryness. And then mine were more mood swings and night sweats.”
According to Jessica Kassis, MD, a board-certified ob-gyn and founder of Radiant Women’s Health in Menlo Park, California, perimenopause symptoms run the gamut from hot flashes to odd things like itchy ears, dizziness, burning feet, and a sensation people describe as “brain zaps.” “We have a ton of estrogen receptors in every part of our body — in our joints, in our guts, in our brain, everywhere,” she explains, noting that the fluctuation of estrogen levels can affect any one of those systems.
When to Consult Your Doctor
If you suspect you’re experiencing symptoms of perimenopause, it’s worth setting up an appointment with your provider to get the conversation started. However, according to Coleman, there is no actual test for perimenopause, because your hormones are fluctuating so much, and a single test would just tell you where your hormone levels were at the moment your blood was drawn. As a result, Dr. Kassis says, “Perimenopause is a diagnosis of exclusion,” meaning you’ll need to see your doctor to ensure that your symptoms are not a result of thyroid issues, a heart condition, or something as simple as an iron deficiency.
That’s not to say that you aren’t also in perimenopause, but it’s important to know whether there is a serious health condition you need to address too.
Hormone Therapy
Since, by doctors’ own admission, perimenopause has not historically been covered much in medical school, it can be hard to find a good healthcare provider who will treat it to your satisfaction. Telehealth companies have popped up to fill this void. Some telehealth providers will ask for your health records or order lab testing before prescribing anything. Be wary of any service that is in a hurry to prescribe treatment without getting all of your health details right beforehand, Coleman says.

For Video Doctor Visits
Midi
While Midi provides services for women in menopause and perimenopause, its founder was inspired by the gap in care for perimenopause and menopause, and that focus is evident. Symptoms like hair loss, hot flashes, low sex drive, and skin changes get special callouts on the site, so you know you’re in the right place. After you fill out an intake form describing your symptoms, you’ll be set up with a half-hour virtual appointment with a clinician who will develop a care plan for you.
You might need to undergo some testing to make sure your symptoms aren’t caused by a thyroid condition, and Midi will help coordinate it with a lab near you. Depending on what you need, your clinician may prescribe hormonal or nonhormonal medications, which will be sent to your local pharmacy. The site sells its own supplements (such as fiber, omega-3s, berberine, and cortisol support), so don’t be surprised if those are included in your regimen. It also provides coaching on various lifestyle changes that may help with symptoms like insomnia. Best of all, Midi has no subscription cost, and visits are covered by many insurance plans. Without insurance, it’s $250 for the first visit, $150 for follow-ups (medicines and lab work not included).
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For Fast Service
Alloy
Alloy skips lab tests and video visits and gets straight down to business. After filling out your intake form, the site promises that a doctor will have a personalized treatment plan ready for you within 12 hours. That may include hormone therapy, as well as prescriptions for skin care, sexual wellness, weight loss, hair loss, and gut health. If you have questions for your clinician, you have unlimited access to them via messaging. After the $49 fee for your initial consultation, you’ll only pay for medications mailed directly to you. The service does not take insurance, but you may be able to submit medication receipts to your insurance provider for reimbursement.
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For Community Support
Winona
Winona is another platform that offers an efficient way to get hormone therapy without a visit to the doctor. The site is specifically for perimenopause and menopause treatments. The brand sells its own bioidentical hormone medications (tablets, creams, patches, capsules), dehydroepiandrosterone (DHEA, a hormone that promotes the production of estrogen and testosterone), estriol face cream, a minoxidil serum for hair loss, and a sleep medication. It also offers its own supplements. You will have your own assigned clinician, but your communication with them is solely through messaging via the patient portal. There’s no subscription fee or charge for doctor communications; the only cost is for the medications. Winona does not take insurance, however.
One thing that distinguishes Winona is the site’s community emphasis. There’s an active message board for discussions about perimenopause and menopause, a regular book club, live Q&A sessions with doctors, and opportunities to meet in person with other members of the community. The site even helps people organize their own meetups if they’d like.
For more providers, read our list of the best places to get HRT online.

For an Easy Prescription Process
Pandia Health
This site offers a streamlined approach to getting birth control (whether for contraception or perimenopause treatment), hormone therapy, and nonhormone medications like Veozah (for hot flashes) mailed directly to you. After you fill out your intake form, a Pandia doctor will use the company’s AI technology to determine the right prescriptions for you. You won’t need to do any additional lab testing or virtual visits with these doctors (although they may recommend independent testing for specific health concerns that require further investigation). There’s a subscription cost (from $34.99 a month to $69 a month), plus the cost of your meds, which may be covered by your insurance. The catch is that Pandia can only prescribe in 14 states.
Diet and Supplements

Whether you’re avoiding hormone therapy or you want to complement your medical treatment with other approaches, you may be able to improve your symptoms through diet and exercise. Because inflammation and changes in weight are common symptoms of perimenopause, many people will choose this time to cut out things like processed sugar. But cutting things out of your diet isn’t the only approach.

To Protect Your Bones
Forest Leaf Vitamin D3
“In the Northeast, it’s very hard to get enough vitamin D from the sun, and vitamin D is not found in tons of foods,” says DeLorenzo.

For Iron Deficiency
Nutricost Iron Tablets (as Ferrous Sulfate)
Not everyone needs an iron supplement, but a deficiency of this mineral can cause symptoms similar to those associated with perimenopause — namely fatigue, difficulty focusing, and inflammation.
“People with heavy periods sometimes can become iron deficient, and interestingly, iron deficiency symptoms are very similar to a lot of the perimenopausal symptoms,” Kassis shares. “I had one patient who’s had a lot of these kinds of ‘brain zap’ symptoms: disequilibrium or dizziness. It turned out she was super iron deficient, and when we fixed that, those went away.”

For Maintaining Muscle Mass
Legion Whey+ Grass-Fed Whey Protein Isolate Powder
Though DeLorenzo believes that today’s protein-maxxers have gone a little overboard with their daily intake recommendations, it is a good idea to increase your protein intake as you age. “In perimenopause, because lean body mass is decreasing, it is helpful to go toward 20 to 30 percent of your diet,” she says, or around 1.5 grams of protein per kilogram (2.2 pounds) of body weight. This protein powder contains 22 grams of protein from grass-fed cows and 0 grams of added sugar. It’s sweetened with stevia and comes in delicious flavors like Dutch Chocolate, Birthday Cake, Orange Cream, and S’mores (also available in unflavored).

For Sounder Sleep
Double Wood Supplements Magnesium Glycinate Supplement
Magnesium is easily depleted in our bodies, DeLorenzo says, but you can boost your level with some simple dietary tweaks: “Foods you can eat that help to increase your magnesium intake are things like beans, chickpeas, cannellini beans, kidney beans, walnuts, almonds, cashews, peanut butter, almond butter, avocados, and chocolate,” she notes. Still, many of us aren’t getting enough of this mineral, and that may actually be impacting our sleep.
Read about more dietitian-recommended supplements for perimenopause.

For Building Back Brains and Muscle
BUBS Naturals Boost Creatine Monohydrate
I’ve been using BUBS Naturals brand for a few months, and I like that it’s completely tasteless and blends well into my smoothies. It’s NSF Certified for Sport, third-party tested, and the company donates 10 percent of its profits to veteran-focused charities.

A Smoothie Upgrade
Califia Farms Organic Soymilk
“Since drinking a glass of soy milk every day, and then [eating] occasional tofu on top of that, I have no more night sweats and hot flashes at all,” DeLorenzo says. ”And if I slip, I notice it.” While this won’t necessarily work for everyone, she says that it’s a good place to start.
Other Sleep Aids


To Block Out Your Partner’s Snores
Loop Quiet 2 Earplugs
Sometimes the problem isn’t you, it’s your surroundings. Loop’s reusable silicone earplugs seal out whatever noises might be keeping you up, and they are truly comfortable as well. They come with four ear-tip sizes, and once you get the right fit, they really stay in. I use mine at night when my husband’s snoring gets unbearable, as well as when I’m on vacation in a place with noises I’m not used to. Loop also has a new Dream earplug that’s meant for side sleepers, but I have yet to try them.

To Stay Cool
Slumber Cloud Performance Tencel Sheet Set
These sheets helped editor Olivia Campbell get a good night’s sleep, by helping her combat the tossing and turning she was doing due to overheating and night sweats. They’re made from a wood-based Tencel lyocell and patented Outlast viscose blend that wicks moisture while remaining breathable to help regulate temperature. They also get softer with every wash.

To Unwind Before Bed
Hatch Sleep Clock
While attending to your body’s needs will go a long way toward improving your sleep, it also helps to introduce some good habits for your mind. The Hatch Sleep Clock can play meditations, sleep stories, soothing sounds, or music — and accompany it with dimming, colored lights — at a set time each night to ease you into a bedtime routine without your phone. It also tracks your sleep patterns nightly without a wearable device, using low-power radio signals. The results will help you learn what habits help you get the best sleep.
Sexual Health

Systemic and local hormone therapy can help these symptoms. “I’m a huge fan of using vaginal estrogen, both internally and externally,” says Kassis. “There are also other hormones that we can use vaginally, like DHEA, which is somewhat harder to get covered by insurance, but is really helpful. For some women, we’ll use topical testosterone for sexual dysfunction. Sometimes women in perimenopause will have testosterone supplementation [via] a cream on their leg.”
Instead of or in addition to hormone treatment, Kassis and Coleman suggest hyaluronic acid suppositories, vaginal moisturizers, and lube. Plus, Coleman reminds us, “for women, our sexual function is tightly connected to our emotional state. So, if we’re stressed with kids, with work, with taking care of our parents, with stress in our relationship, we don’t feel like having sex, and we’re going to be dry as a bone.” She often tells couples to treat stress relief — especially redistributing some of those household and caretaking duties — as foreplay.

A Nonhormonal Pick
Bonafide Revaree Vaginal Dryness Relief

A Water-Based Option
Good Clean Love Almost Naked Organic Personal Lubricant
Water-based lubricant is best to use with condoms or sex toys — and by the way, vibrators are a great tool for improving sexual function in women. This lube has moisturizing aloe vera and no potentially irritating glycerin, parabens, or petrochemicals. The brand claims that this formula also lowers pH levels and encourages healthy bacteria to grow, which is great news for women who tend to suffer from yeast infections or other microbiome imbalances.
Skin and Hair Products

Speak to your doctor about anything truly concerning (and don’t forget that annual checkup with a dermatologist). In the meantime, try some of these “anti-aging” products for your hair and skin.

A Prescription Boost
Midi Estriol+ Face Cream
This particular estriol cream formula includes hyaluronic acid and niacinamide to support hydration and protect the skin barrier.

A Budget-Friendly Face Cream
cocokind Resurrection Polypeptide Cream

For Hair Loss
Hers Minoxidil Foam for Women

For Itchy Ears
Hyland’s Dry Ear Relief Oil
Itchy ears are one of the weirdest potential perimenopause symptoms — and even Coleman was tempted to dismiss it as a social media phenomenon until she experienced it herself. The most likely culprit is dry skin and very sensitive nerve receptors in the ear canal, she says. And while you may be able to cure it with olive oil or coconut oil, that can get messy. These easy-to-use drops from Hyland’s have hemp seed oil, argan oil, jojoba oil, camellia oil, avocado oil, coconut oil, and apricot kernel oil to moisturize and eventually ease the itch.
Other Things You Can Do
Just as the symptoms of perimenopause can be surprisingly broad, so can the ways you cope with them. They definitely don’t all involve prescription medications and products you buy. Consider adding these to your perimenopause tool kit:
- A new fitness routine that includes strength training but isn’t so rigorous that it causes an increase in cortisol levels. “The key with exercise during perimenopause is to not overdo it, because that can cause inflammation in the body and make it counterproductive,” says DeLorenzo, who also teaches yoga.
- It’s a good idea to speak to someone about any depression and anxiety that have come up following these hormonal shifts. People with ADHD also sometimes face bigger challenges as they reach perimenopause. Through all of this, external factors in your life may be changing too. You can find great therapy online, if you’re not already seeing a therapist.
- My group chat with my college friends has become an unofficial perimenopause support group. If you don’t already have friends to talk to about these things, there are online resources available, via Reddit and sites like Winona.
Is HRT Safe?
FAQ
Most women go through menopause between the ages of 45 and 55, so if you’re on the early end of that, you can definitely experience perimenopause symptoms in your thirties. “I myself started having symptoms as early as 36,” DeLorenzo says.
All three of the experts I spoke to agree that changes to diet and lifestyle can help women cope with many perimenopause symptoms. You may even be lucky enough to have few or only minor symptoms throughout perimenopause. But if you find that any of your symptoms are severely interfering with your well-being, such as hot flashes that keep you up every single night, prescription medications may be your best bet for feeling better.
The supplement industry isn’t regulated in the United States, which is why all three experts I spoke to urge people to approach these products with caution and to always look for labels that say they’re third-party tested. “Otherwise, they could literally put caffeine in a pill and put it in a bottle,” Kassis says.
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