How to Safely Remove Rodent Droppings So You Don’t Get Sick

How to Safely Clean Rodent Droppings, Protect Your Home from Pests, and Prevent Diseases Like Hantavirus

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If you live in a city, chances are you’ve encountered rodents before. And while many of us have begrudgingly accepted the presence of rats and mice as a less-than-desirable part of urban life, the recent outbreak of hantavirus aboard a luxury cruise ship underscores the risk these rodents pose to our health.

Scientists have identified approximately 15,205 rodent-associated viruses across 32 viral families. Many of these viruses, including hantavirus, primarily spread to humans through tiny airborne particles of dried droppings or urine. Each one can cause serious symptoms, days or even weeks after exposure. In the case of hantavirus, the symptoms, which require immediate medical attention, include fever, muscle aches, fatigue, and headaches, followed by a cough and breathlessness.

The Centers for Disease Control and Prevention (CDC) advises a multipronged approach to preventing these viruses from spreading. The primary recommendations include securing food sources, disposing of rodent waste, plugging any gaps in your home where rodents could enter, and following a specific cleaning protocol.

Droppings should be soaked in a bleach-based spray for five minutes, then removed using paper towels and placed directly into a covered garbage can that is regularly emptied. Don’t sweep or vacuum dry droppings, as that could send infected droplets into the air. Always wear a protective N95 mask and disposable gloves while you work.

Whether you’ve spotted disconcerting signs of rodents in your home or want to take preventive measures as part of your spring cleaning efforts, these essentials will help keep your household healthy.

Cleaning Supplies

Once you’ve spotted rodent droppings on your property, make cleaning them up your first priority. Your favorite eco-friendly cleaning spray isn’t going to cut it for this job, which is why we recommend these bleach-infused formulas. Just remember: Never mix bleach with other cleaners to avoid toxic fumes, and keep the space well ventilated. Finally, store bleach safely, keeping it locked away or out of children's reach.

a photo of Clorox Healthcare Bleach Germicidal Cleaner Spray.

Clorox Healthcare Bleach Germicidal Disinfectant Trigger Spray

You can rely on this hospital-grade Clorox spray to obliterate any nasty viruses. It's also bactericidal, fungicidal, and sporicidal, and registered by the EPA to kill norovirus when used as directed.

The bleach-based formula is safe for use on a range of nonporous surfaces, including plastics and metals, and it claims to kill 50 or more microorganisms in three minutes or less. If there are children and pets in your home, remember to follow the product’s instructions closely. Try to keep pets and children out of the room until the cleaned surfaces are fully dry and the bleach smell has dissipated.

juniper surface wipes

Juniper Clean Surface Cleaning Wipes with Bleach

Once the droppings have soaked in bleach for a few minutes, wipe them up and dispose of them in a secure plastic bag. Paper towels are fine for this job, but some brands become fragile and tear when wet. Opt for thick, robust disposable wipes instead—and it doesn’t hurt to choose a bleach-saturated option, like these from Juniper Clean.

Face and Hand Protection

The last thing you want during a cleanup is to get particles of rodent droppings or urine on your hands or near your face, where you might inhale them. These gloves and masks will reliably protect you while you get the job done.

a photo of ForPro Disposable Nitrile Gloves.

ForPro Nitrile Gloves 4 Mil.

It could be a disaster if your gloves tear midway through cleaning. You won’t have to worry about that with this pair, which is made of thick, chemical- and puncture-resistant nitrile — a synthetic, petroleum-based material that is safe for those with latex allergies.

They’re available in sizes small to extra-large to ensure a comfortable fit, and the textured finish allows you to grip and clean wet surfaces easily.
3M Aura particulate respirator mask

3M Aura Particulate Respirator 9205+ Plus N95 Mask

When shopping for a mask, the CDC recommends getting one that’s approved by the National Institute for Occupational Safety and Health.

These N95s fit the bill. The mask’s three-layer design boasts a high level of protection against respiratory viruses filtering 95 percent of non-oil-based particles. (N99s and N100s are also available, and have a slightly higher level of protection). Its curved design hugs facial contours for a secure, comfortable fit.
a photo of LAUCO Premium Respirator Kit.

LAUCO Premium Respirator Kit

If you think your rodent issues may take time to resolve and involve multiple clean-ups, you might consider investing in this reusable respirator kit. The half-face shield and safety glasses provide a secure barrier, and the dual-filtration system effectively blocks 97 percent of airborne particles, according to the brand. The kit includes 10 cotton filters, 2 filter cartridges, and 2 filter covers, so you can reuse it as needed.

Pest Barriers, Traps, and Repellents

No amount of cleaning will suffice if rodents keep returning to your home. This selection of barriers, traps, and essential oil-infused repellents will help prevent unwanted visitors from returning.

Rodent Barrier Kit

PAMAZY Rodent Barrier Kit

Rodents can squeeze through surprisingly small gaps, so take stock of any holes in the walls or around piping and vents. This easy-to-use kit contains extra-strong wire wool and spray foam sealant to help fill those gaps and secure your home. If you’re worried that there might be a nest somewhere, it might be time to call in a pest control professional. Many companies offer free inspections to properly identify problem areas before presenting a treatment plan.

Cleaning up droppings will become a Sisyphean task if you don’t also get rid of the culprits themselves. These reusable rat traps lure rodents with bait (peanut butter works well), then use a powerful spring mechanism to catch and instantly kill them as they enter the chamber. The trap is easy to empty directly into a trash bag, and its covered design is safe for use around pets and children.

a photo Mighty Mint Rodent Repellent Pouches with Glue Dots.

Mighty Mint Rodent Repellent Pouches

If you can’t face using a trap, there are more humane options available. Studies have shown that the strong scent of essential oils can temporarily repel rodents.

 These pouches combine a potent mix of peppermint, cinnamon, and castor oil. Intended for indoor use, they come with sticky patches so you can quickly affix them where needed—cars, crawlspaces, attics, etc. Once you’ve strategically placed your pouch, the scent will last around a month before it needs replacing.

Pest-Proof Storage

One of the main factors that attracts rodents is a ready supply of food. If you’re seeing pests and you’ve got unsealed boxes of cereal or bags of chips, there’s a clear indication of what you can do to mitigate the situation. Keep your pantry staples, pet treats, and garbage sealed up tight with these easy storage solutions.

Airtight food storage containers

Vtopmart Airtight Food Storage Containers With Lids, 24 pcs

Where there is easily accessible food, there may be rodents. These scavengers are tempted by any food items that are not properly sealed, as well as any packaging that they can gnaw through. This 24-piece collection of airtight storage containers will keep your pantry secure. Perfect for shelf-stable items such as pasta, cereal, candy, nuts, dried fruits, and dried beans, the BPA-free set also comes with 24 labels for easy organization.

a photo of Gamma2 Vittles Vault Dog Food Storage Container.

Gamma2 Vittles Vault Dog Food Storage Container

It’s not just human food rats will go after; dog biscuits make an attractive rodent meal too. Keep your furry friend’s food tightly sealed in this storage container. Its food-safe, BPA-free design and airtight locking system maintain food freshness—a win for pets, too.

a photo of United Solutions 32 Gallon Wheeled Outdoor Garbage Can.

United Solutions Wheeled 32-Gallon Outdoor Trash Can, 2 Pack

If they get the opportunity, rats will gnaw through trash bags in search of food scraps. Securing your trash — indoors and outdoors — gives them one less reason to visit your property. This pair of 32-gallon garbage cans is roomy enough for all your household trash, and their snap-lock lids ensure rodents don’t stand a chance at getting inside. Additionally, the wheels and handle make it easy to bring your trash to the curb on collection day.

What should you do if you accidentally vacuum up mouse droppings?

The CDC advises against sweeping or vacuuming up mouse droppings because these cleaning methods may aerosolize contaminants, causing accidental inhalation. But don’t panic if you already whipped out the Dyson. Open doors and windows to increase air circulation and turn on your air purifier if you have one. Next, put on a mask and gloves (if you haven’t already) and take the vacuum outdoors to safely dispose of the droppings in a trash bag. Finish cleaning with CDC-recommended bleach spray and paper towels, and if you develop any symptoms of illness, consult your doctor immediately.

How do you mouse-proof a kitchen?

If mice are finding their way to your kitchen, they’re undoubtedly searching for food and water. First, secure all food and water sources using our recommended storage solutions, then examine every inch of your space for possible entry points. These can be as small as ¼ inch wide — the diameter of a pencil — so check under the sink, around vents, and anywhere electrical wiring passes through the wall. If you find a hole, use a rodent barrier kit to seal it and prevent the mouse from reentering.

What are the best ways to prevent pests in your home?

Play rodent psychologist for a moment and imagine what in your space might appeal to them. Perhaps there are obvious entry points to come and go through; reliable food sources like open pet food, pantry items, uncovered garbage, and garden herbs and veggies; or clutter for them to hide behind. Make an exhaustive list and tackle each issue — either on your own or with help from a pest control professional.

Even if you’re not concerned about rodent droppings and rodent viruses, having a clean home in general is important for your well-being. After testing dozens of cleaning products, we created this list of our favorite picks for a sparkling, germ-free home.

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Resources
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  5. Masks and Respiratory Viruses Prevention. Centers for Disease Control and Prevention. August 18, 2025.
  6. Goran Jokić, et al. Wild Mus musculus response on two different essential oils with high repellent potential. Journal of Stored Products Research. 2018.
  7. How to Seal Up to Prevent Rodents. CDC. 2024.