Bothered by Eye Redness? New Brightening Drops Now Available Without a Prescription
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There’s a New Kind of OTC Eye Drop for Redness Relief

The FDA approved Brytly eye drops, which offer up to 12 hours of ‘whiter, brighter eyes,’ without a prescription.
There’s a New Kind of OTC Eye Drop for Redness Relief
Alcon
The U.S. Food and Drug Administration (FDA) has approved a new over-the-counter eye drop to treat eye redness. Brytly is the first nonprescription whitening eye drop to contain apraclonidine, an active ingredient already used in prescription medications.

“This gives consumers another option for occasional redness relief, using a medication ophthalmologists have worked with for years at higher prescription strengths,” says Bavand Youssefzadeh, DO, an ophthalmologist with Cedars-Sinai in Los Angeles and a cofounder of the Global LASIK and Cataract Institute, both in California, who wasn’t involved with the product’s development.

“What’s new is the lower-concentration, nonprescription formulation for redness caused by minor irritation,” Dr. Youssefzadeh says.

There are a few limitations to consider before you try Brytly, including how often to apply it.

Brytly Whitens Eyes by Narrowing Blood Vessels

Brytly (apraclonidine ophthalmic solution 0.125%) works by stimulating alpha-adrenergic receptors in the eye. “This causes blood vessels on the surface of the eye to narrow and become less visible,” Youssefzadeh says.

In a press release, the maker of Brytly, Alcon, said the product can deliver “up to 12 hours of whiter, brighter-looking eyes.” The drops do not contain bleach or dyes.

Brytly isn’t the first drug in this class available without a prescription. “This is the first OTC apraclonidine product, rather than the first redness drop of this general type,” Youssefzadeh says. Another well-known OTC product, Lumify Redness Reliever Eye Drops, contains the active ingredient brimonidine, which belongs to the same broad drug family and can reduce eye redness for up to 8 hours.

Youssefzadeh says Brytly is simply another choice for consumers to treat eye redness. He cautions against assuming that Brytly is “better” than Lumify because it lasts longer. “I would avoid assuming it has less rebound redness or better tolerability without comparative data,” he says.

How Brytly Got Approved

Brytly’s active ingredient, apraclonidine, is used in higher concentrations in prescription form. The new over-the-counter product didn’t undergo any additional clinical trials. Instead, the approval is part of the FDA’s Public Health Pillars, a policy designed to increase the availability of certain medications.

“Expanding access to safe and effective nonprescription treatments is a priority for FDA,” said Mike Davis, MD, PhD, the director of the FDA Center for Drug Evaluation and Research, in a statement. “Approval of Brytly gives consumers a new nonprescription option to manage eye redness conveniently and without needing to see a healthcare provider.”

Limitations on the Use of Brytly

Brytly is approved for adults and children ages 12 and older. It should not be used more than twice a day.

“Twice daily is the maximum approved frequency, and patients should follow that limit,” Youssefzadeh says. “More frequent dosing shouldn’t be assumed to provide more benefit. If someone needs repeated applications to keep their eyes comfortable or clear, that’s a reason to investigate the redness.”

Users should remove contacts before using Brytly and wait at least 10 minutes after applying the drops before inserting contacts again. Users who plan to use another kind of eye drop should wait five minutes between applications of each product.

People should stop using Brytly and seek medical advice for pain, vision changes, continued redness or irritation, or symptoms that worsen or last more than three days.

People who regularly rely on an eye drop like Brytly should get an eye exam, Youssefzadeh says. “Reducing redness doesn’t necessarily address what caused it. I would want people to understand that a whiter-looking eye can still have an underlying problem.”

“Dry eye, allergies, eyelid inflammation, and contact lens problems can all require different treatments,” he says. “My advice is to treat the reason the eye is red, rather than simply keep covering up the symptom.”

When Will Brytly Eye Drops Be Available?

Alcon said in its press release that Brytly would be available at retailers “in the coming months.” The company didn’t say how much the eye drops will cost.

EDITORIAL SOURCES
Everyday Health follows strict sourcing guidelines to ensure the accuracy of its content, outlined in our editorial policy. We use only trustworthy sources, including peer-reviewed studies, board-certified medical experts, patients with lived experience, and information from top institutions.
Resources
  1. FDA Approves New Nonprescription Eye Drop for Relief of Eye Redness. U.S. Food and Drug Administration. October 16, 2026.
  2. FDA Approves Alcon’s BRYTLY Redness Reliever Eye Drops for Up to 12 Hours of Whiter, Brighter-Looking Eyes. Business Wire. October 16, 2026.
  3. FDA’s Public Health Pillars. U.S. Food and Drug Administration. July 15, 2026.

Emily Kay Votruba

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Korin Miller

Korin Miller

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Korin Miller is a health journalist with more than a decade of experience in the field. She covers a range of health topics, including nutrition, recent research, wellness, fitness...