Kick Your Cough to the Curb With These OTC Cough Syrups, Recommended by Doctors
We’ve all experienced it before: a persistent cough that makes everything difficult — sleeping through the night, focusing on work, or simply getting through the day. An over-the-counter (OTC) cough syrup is a common solution, but not all cough medicines are equal, and choosing the right product depends on the type of cough you’re dealing with.
Cough syrups generally fall into two categories: suppressants and expectorants. “A cough suppressant helps reduce how often and how hard you cough,” says Allie Buttarazzi, MD, a diplomate of the American Board of Lifestyle Medicine and double board-certified physician who is co-owner of Maine Street Medical in Brunswick, Maine. “I recommend them when you have a persistent, dry cough. An expectorant thins mucus so you can clear it more easily,” Dr. Buttarazzi explains, “and can be helpful if you have a ‘junky,’ productive cough but can’t seem to bring the mucus up.”
Because the cough syrup aisle is crowded with options, some of which also contain decongestants, pain relievers, and antihistamines, we spoke with three board-certified physicians to see what they most often recommend for common coughs. Here are the best OTC cough syrups that we trust to help you breathe, sleep, and get through the day.
Our Top Picks for Best OTC Cough Syrups
- Best for wet coughs: Mucinex Fast-Max DM Max
- Best for allergies: Benadryl Allergy Liquid
- Best for adults: Robitussin Honey Cough and Chest Congestion DM
- Best multi-symptom: Robitussin Cough and Chest Congestion DM
- Best for travel: Delsym Adult Cough Suppressant Liquid
- Best for young kids: Zarbee’s Children’s Daytime Cough Syrup + Immune
- Best for nighttime relief: Robitussin Maximum Strength Nighttime Cough DM
- Best nondrowsy formula: GoodSense 12 Hour Cough DM
When to Consult Your Doctor
While a mild cough from the common cold often improves on its own, persistent coughs lasting longer than eight weeks should be evaluated by your doctor. Additionally, if you experience symptoms such as shortness of breath, headaches, drowsiness, or a high fever, or are coughing up mucus that is yellowish-green or bloody, you should seek medical attention immediately. “For kids under 4, most pediatricians do not recommend OTC cough syrups,” says Chrissie Ott, MD, a triple board-certified physician practicing in Portland, Oregon. “If a young child is coughing and needs symptom management, a physician’s input is warranted.”

Best for Wet Coughs
Mucinex Fast-Max DM MAX
Pros
- Contains both cough suppressant and expectorant
- Nondrowsy
- Free of artificial colors, dyes, alcohol, sugar
Cons
- Only for ages 12 and older
- Not recommended for those taking MAOIs
We like that this product is sugar-free. Instead, it contains sorbitol and sucralose as sweeteners. It’s also a nondrowsy formula that can be used during the day or night, so you don’t need to purchase multiple products — this one covers you all day. Like many other cough syrups, it’s not recommended for children under 12. Additionally, people taking prescription monoamine oxidase inhibitors (MAOIs) should consult their doctor before using this product.
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Best for Allergies
Benadryl Allergy Liquid
Pros
- Contains diphenhydramine HCl
- Relieves cold and allergy symptoms
- Alcohol-free
- Affordable
Cons
- Doesn’t contain an expectorant
- May cause drowsiness
Finally, although Benadryl Allergy Liquid is effective in relieving coughs associated with allergies or the common cold, it doesn’t contain an expectorant, so it may not be helpful for people with a wet cough or excessive mucus. However, if you’re experiencing a dry cough or other allergy-like symptoms, this is an effective option.
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Best for Adults
Robitussin Honey Cough and Chest Congestion DM
Pros
- Contains both cough suppressant and expectorant
- Contains Grade A True Source Certified honey
- Free of artificial colors and flavors, gluten-free
- Soothing honey flavor
Cons
- Only for adults, children 12 and older
- Not recommended for those taking MAOIs
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Best Multi-Symptom
Robitussin Cough and Chest Congestion DM
Pros
- Contains both cough suppressant and expectorant
- Contains soothing menthol
- Nondrowsy
- Alcohol-free
Cons
- Only for adults, children 12 and older
- Not recommended for those taking MAOIs
“I’m not a fan of most ‘all-in-one’ formulas,” says Buttarazzi, “as they often pack in four or more ingredients you may not need and can make it easy to double up on ingredients, such as acetaminophen.” However, Buttarazzi notes that Robitussin Cough and Chest Congestion DM is different. “It combines dextromethorphan to quiet a cough,” she explains, “and guaifenesin to thin and loosen mucus — nothing extra.”

Best for Travel
Delsym Adult Cough Suppressant Liquid
Pros
- Travel-friendly 3-ounce bottle
- Nondrowsy
- Only one active ingredient
- Relieves cough for up to 12 hours
- Alcohol-free
- Sulfite-free
Cons
- Doesn’t relieve congestion or mucus
- Not recommended for those taking MAOIs
When you’re traveling, the last thing you want is to become drowsy while you’re on the go. “Delsym keeps it simple with a single active ingredient — dextromethorphan,” says Buttarazzi, “making it a solid choice for a dry, nagging daytime cough.” She adds that most people find it nonsedating, but everyone has a unique body chemistry, so it’s best to try it at home first to see how you respond.
We also love that Delsym Adult Cough Suppressant Liquid comes in a travel-friendly, 3-ounce bottle. Its small size means you can take it through airport security, which can be beneficial if you have a long flight and will need a second dose while you’re flying. However, it doesn’t relieve congestion or mucus, so it’s not the best choice if you have a stuffy nose or wet cough.

Best for Young Kids
Zarbee’s Children’s Daytime Cough Syrup + Immune
Pros
- Drug-free cough relief for young children
- Contains dark honey, vitamin D, zinc
- Free of alcohol, artificial sweeteners, flavors, dyes
- Free of gluten, dairy, egg, and peanut
Cons
- Not suitable for children under 2
- Mixed berry flavor may not appeal to all
When it comes to cough syrups for young kids, Dr. Ott only recommends treating a cough “when it’s interfering significantly with sleep or causing pain.” Otherwise, coughing is a good thing — it’s necessary to help move mucus the body is trying to eliminate, she explains. However, if your pediatrician has ruled out other causes of coughing, such as asthma and pneumonia, Ott recommends honey or a cough syrup like Zarbee’s, which contains honey to coat and soothe the throat. We love Zarbee’s Cough Syrup + Immune because, in addition to dark honey, it also contains three ingredients that may help support immune health — vitamin D, zinc, and elderberry fruit extract.

Best for Nighttime Relief
Robitussin Maximum Strength Nighttime Cough DM
Pros
- Contains dextromethorphan and antihistamine
- Contains soothing menthol
- Multi-symptom relief
- Alcohol-free
Cons
- May increase risk of urinary retention, morning grogginess
- Not recommended for those taking MAOIs
- Not suitable for children under 12
Buttarazzi generally recommends choosing nondrowsy cough syrups like the ones listed above, even at night, because the nighttime syrups typically rely on sedating antihistamines. However, if coughing is truly keeping you from sleeping, she recommends Robitussin Maximum Strength Nighttime Cough DM, noting that it only contains a low dose of antihistamine (plus dextromethorphan to help suppress a cough).

Best Nondrowsy Formula
GoodSense 12 Hour Cough DM
Pros
- Nondrowsy
- Only one active ingredient
- Affordable
- Relieves cough for up to 12 hours
- Alcohol-free
Cons
- Contains sodium metabisulfite
- Doesn’t relieve congestion or mucus
- Not recommended for those taking MAOIs
If you’re looking for a nondrowsy cough syrup, GoodSense 12 Hour Cough DM is an affordable option. It contains just one ingredient — dextromethorphan polistirex extended release — which Buttarazzi says shouldn’t cause drowsiness in most people.
The time-release form of dextromethorphan provides relief for up to 12 hours. Plus, because it only contains dextromethorphan, it can be used in children ages 4 and older; most other cough syrups that contain an expectorant are not appropriate for children under 12 years.
However, because it doesn’t contain an expectorant, it may not be the best choice for individuals with a wet cough or congestion caused by excessive mucus. It also contains sugar, which some people may want to avoid. And it contains sodium metabisulfite, which may trigger allergic-type reactions in people with a sulfite sensitivity.
Comparison Table
Children 12 and older: 20 mL; Adults: 20 mL
How We Chose the Best OTC Cough Syrups
You deserve recommendations you can trust, which is why we compiled this list using a clear, evidence-informed process. To ensure accuracy and safety, we consulted three board-certified physicians:
- Allie Buttarazzi, MD, a diplomate of the American Board of Lifestyle Medicine and double board-certified physician who is co-owner of Maine Street Medical in Brunswick
- Heather Gosnell, MD, a board-certified pediatrician in Phoenix
- Chrissie Ott, MD, a triple board-certified physician in Portland, Oregon
Their insights helped us evaluate how different OTC cough syrups work and which ones are most appropriate for different individuals and situations. We considered factors like active ingredients, alcohol and sugar content, dosage and frequency, flavor, age range, and price. By weighing these criteria with input from our experts, we identified the OTC cough syrups most likely to provide safe and effective relief for a range of different types of cough.
What to Look for When Buying OTC Cough Syrups
Not all cough syrups work the same way, so it’s important to choose one that’s designed to treat the symptoms you’re experiencing. Here are some factors to keep in mind when shopping for OTC cough syrups:
- Active Ingredients Look for expectorants (like guaifenesin) if you have a wet cough and need to loosen mucus, suppressants (like dextromethorphan) if you have a dry, hacking cough, or antihistamines (like diphenhydramine) if your cough is related to allergies.
- Age Range Many cough syrups aren’t safe for young children, so it’s important to choose products that are designed for the age range of the person taking the medication.
- Dosage and Frequency Determine how often you’ll need to take it, and ensure that it aligns with your schedule. Some cough syrups contain timed-release ingredients, which may be more convenient, as you won’t need to take the medicine as often.
- Alcohol or Sugar Content People with diabetes, children, or those avoiding alcohol may need to avoid cough syrups with these ingredients.
FAQ
A cough suppressant (like dextromethorphan) helps reduce the frequency and severity of a cough, and it can be useful when you have a persistent, dry cough. An expectorant (like guaifenesin) helps thin mucus, making it easier to clear. This makes it a good choice if you have a wet, productive cough but are struggling to clear the mucus.
“I tell my patients to look for dextromethorphan if they need a suppressant, and guaifenesin if they need an expectorant,” says Buttarazzi. As for ingredients to avoid, “I generally recommend skipping products with a decongestant like phenylephrine, since it isn’t very effective,” she adds.
Buttarazzi also recommends avoiding antihistamines like doxylamine or diphenhydramine, unless absolutely necessary, as they can make you drowsy. Finally, “I also steer patients away from combination syrups that contain acetaminophen,” she explains, “and if you do need it, it’s best to take it separately, so you can control the dose.”
“OTC cough syrups are unsafe for children under 4,” says Dr. Gosnell, “and not recommended under 6, as studies show no benefit in younger kids.” She adds that these medications can cause harmful side effects in children, including a faster heart rate, restlessness, confusion, and sleepiness.
When choosing a cough syrup for children, Ott recommends selecting single-ingredient cough syrups whenever possible to avoid overdosing on other ingredients, such as antihistamines and decongestants.
For most people, there aren’t many downsides to taking OTC cough syrups, says Buttarazzi. However, some people may notice mild drowsiness from dextromethorphan and added antihistamines, so try your first dose when you don’t need to drive or work, she adds.
“Nighttime cough syrups have not been shown to improve sleep in children,” says Gosnell. For adults, Buttarazzi generally recommends nondrowsy options, unless they are absolutely necessary, as many nighttime syrups rely on sedating antihistamines that can leave you groggy in the morning and may increase the risk of urinary retention, especially in older adults.
If you choose to use cough syrups in your children, Gosnell recommends sugar-free and alcohol-free versions. “Sugar offers no symptom relief and can cause tooth decay and provide excess calories,” she explains, “while alcohol also provides no benefit and may cause central nervous system depression, low blood sugar, and accidental overdose.”
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