8 Best Doctor-Recommended OTC Cough Syrups

Kick Your Cough to the Curb With These OTC Cough Syrups, Recommended by Doctors

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We’ve all experienced it before: a persistent cough that makes everything difficult — sleeping through the night, focusing on work, or simply getting through the day. An over-the-counter (OTC) cough syrup is a common solution, but not all cough medicines are equal, and choosing the right product depends on the type of cough you’re dealing with.

Cough syrups generally fall into two categories: suppressants and expectorants. “A cough suppressant helps reduce how often and how hard you cough,” says Allie Buttarazzi, MD, a diplomate of the American Board of Lifestyle Medicine and double board-certified physician who is co-owner of Maine Street Medical in Brunswick, Maine. “I recommend them when you have a persistent, dry cough. An expectorant thins mucus so you can clear it more easily,” Dr. Buttarazzi explains, “and can be helpful if you have a ‘junky,’ productive cough but can’t seem to bring the mucus up.”

Because the cough syrup aisle is crowded with options, some of which also contain decongestants, pain relievers, and antihistamines, we spoke with three board-certified physicians to see what they most often recommend for common coughs. Here are the best OTC cough syrups that we trust to help you breathe, sleep, and get through the day.

Our Top Picks for Best OTC Cough Syrups

When to Consult Your Doctor

While a mild cough from the common cold often improves on its own, persistent coughs lasting longer than eight weeks should be evaluated by your doctor. Additionally, if you experience symptoms such as shortness of breath, headaches, drowsiness, or a high fever, or are coughing up mucus that is yellowish-green or bloody, you should seek medical attention immediately. “For kids under 4, most pediatricians do not recommend OTC cough syrups,” says Chrissie Ott, MD, a triple board-certified physician practicing in Portland, Oregon. “If a young child is coughing and needs symptom management, a physician’s input is warranted.”

Mucinex Fast Max DM Max

Best for Wet Coughs

Mucinex Fast-Max DM MAX

Pros

  • Contains both cough suppressant and expectorant
  • Nondrowsy
  • Free of artificial colors, dyes, alcohol, sugar

    Cons

    • Only for ages 12 and older
    • Not recommended for those taking MAOIs
    When you have a wet cough, Buttarazzi recommends choosing a product that contains an expectorant like guaifenesin to help mobilize the mucus. We chose Mucinex Fast-Max DM MAX Honey & Berry flavored cough syrup for a wet cough because, unlike many other cough syrups for wet cough, it doesn’t contain phenylephrine. Phenylephrine is marketed as a decongestant, but according to Buttarazzi (and the U.S. Food and Drug Administration), it isn’t very effective.

    We like that this product is sugar-free. Instead, it contains sorbitol and sucralose as sweeteners. It’s also a nondrowsy formula that can be used during the day or night, so you don’t need to purchase multiple products — this one covers you all day. Like many other cough syrups, it’s not recommended for children under 12. Additionally, people taking prescription monoamine oxidase inhibitors (MAOIs) should consult their doctor before using this product.

    cough syrup

    Best for Allergies

    Benadryl Allergy Liquid

    Pros

    • Contains diphenhydramine HCl
    • Relieves cold and allergy symptoms
    • Alcohol-free
    • Affordable

    Cons

    • Doesn’t contain an expectorant
    • May cause drowsiness
    We chose Benadryl Allergy Liquid as the best OTC cough syrup to soothe a cough caused by allergies because it contains just one active ingredient: diphenhydramine hydrochloride (HCl). Diphenhydramine relieves several allergy-related symptoms, including itchy, watery eyes; sneezing; a runny nose; and a cough related to allergies or the common cold. Diphenhydramine is an antihistamine that works by blocking histamine (a chemical compound that causes allergy symptoms).

    Benadryl Allergy Liquid is also alcohol-free, affordable (at around $10 per bottle), and can be used in children ages 6 and older. Like many antihistamines, diphenhydramine can cause drowsiness, but it may have the opposite effect in children. If you haven’t taken diphenhydramine before, it’s best to do so at home first, so that you can see how it affects you.

    It also contains sugar, which some people may prefer to avoid.

    Finally, although Benadryl Allergy Liquid is effective in relieving coughs associated with allergies or the common cold, it doesn’t contain an expectorant, so it may not be helpful for people with a wet cough or excessive mucus. However, if you’re experiencing a dry cough or other allergy-like symptoms, this is an effective option.

    cough syrup

    Best for Adults

    Robitussin Honey Cough and Chest Congestion DM

    Pros

    • Contains both cough suppressant and expectorant
    • Contains Grade A True Source Certified honey
    • Free of artificial colors and flavors, gluten-free
    • Soothing honey flavor

      Cons

      • Only for adults, children 12 and older
      • Not recommended for those taking MAOIs
      We chose Robitussin Honey Cough and Chest Congestion DM as the best OTC cough syrup for adults because, in addition to containing active ingredients to control coughing (dextromethorphan hydrobromide) and clear mucus to relieve chest congestion (guaifenesin), it also contains real honey. Honey is a common home remedy for coughs that helps coat and soothe an irritated throat. One study found that honey significantly reduced the severity and frequency of coughing in adults with acute respiratory infections.

      Dextromethorphan was approved as a cough suppressant by the U.S. Food and Drug Administration in 1958 and is still one of the most common OTC cough syrup ingredients.

      Guaifenesin helps clear mucus and relieve cough congestion caused by the common cold and allergies. It works by relaxing the muscles around your airways and drawing fluid into the respiratory tract, which makes the mucus less thick and sticky and easier to clear.

      We also like that this product contains real honey as a sweetener, instead of other types of sugar, and is free of artificial colors. It’s also gluten-free, making it a solid choice for people with celiac disease or gluten intolerance. Finally, dextromethorphan may interact with prescription MAOIs, so it’s best to consult your doctor before taking cough syrups with that ingredient if you’re taking MAOIs.


      cough syrup

      Best Multi-Symptom

      Robitussin Cough and Chest Congestion DM

      Pros

      • Contains both cough suppressant and expectorant
      • Contains soothing menthol
      • Nondrowsy
      • Alcohol-free

      Cons

      • Only for adults, children 12 and older
      • Not recommended for those taking MAOIs

      “I’m not a fan of most ‘all-in-one’ formulas,” says Buttarazzi, “as they often pack in four or more ingredients you may not need and can make it easy to double up on ingredients, such as acetaminophen.” However, Buttarazzi notes that Robitussin Cough and Chest Congestion DM is different. “It combines dextromethorphan to quiet a cough,” she explains, “and guaifenesin to thin and loosen mucus — nothing extra.”

      She recommends choosing the regular-strength version, so that you can start at a lower dose and only increase it to the maximum dosage if truly necessary. We also like that this product contains menthol, which creates a cooling sensation in the throat and airways that can soothe irritation and make it feel easier to breathe.

      It’s also alcohol-free. 
      Delsym cough syrup

      Best for Travel

      Delsym Adult Cough Suppressant Liquid

      Pros

      • Travel-friendly 3-ounce bottle
      • Nondrowsy
      • Only one active ingredient
      • Relieves cough for up to 12 hours
      • Alcohol-free
      • Sulfite-free

      Cons

      • Doesn’t relieve congestion or mucus
      • Not recommended for those taking MAOIs

      When you’re traveling, the last thing you want is to become drowsy while you’re on the go. “Delsym keeps it simple with a single active ingredient — dextromethorphan,” says Buttarazzi, “making it a solid choice for a dry, nagging daytime cough.” She adds that most people find it nonsedating, but everyone has a unique body chemistry, so it’s best to try it at home first to see how you respond.

      We also love that Delsym Adult Cough Suppressant Liquid comes in a travel-friendly, 3-ounce bottle. Its small size means you can take it through airport security, which can be beneficial if you have a long flight and will need a second dose while you’re flying. However, it doesn’t relieve congestion or mucus, so it’s not the best choice if you have a stuffy nose or wet cough.

      zarbees cough syrup for children.

      Best for Young Kids

      Zarbee’s Children’s Daytime Cough Syrup + Immune

      Pros

      • Drug-free cough relief for young children
      • Contains dark honey, vitamin D, zinc
      • Free of alcohol, artificial sweeteners, flavors, dyes
      • Free of gluten, dairy, egg, and peanut

        Cons

        • Not suitable for children under 2
        • Mixed berry flavor may not appeal to all

        When it comes to cough syrups for young kids, Dr. Ott only recommends treating a cough “when it’s interfering significantly with sleep or causing pain.” Otherwise, coughing is a good thing — it’s necessary to help move mucus the body is trying to eliminate, she explains. However, if your pediatrician has ruled out other causes of coughing, such as asthma and pneumonia, Ott recommends honey or a cough syrup like Zarbee’s, which contains honey to coat and soothe the throat. We love Zarbee’s Cough Syrup + Immune because, in addition to dark honey, it also contains three ingredients that may help support immune health — vitamin D, zinc, and elderberry fruit extract.

        This product contains 8 percent of the daily value of vitamin D. Some research shows that because vitamin D plays a role in regulating the immune system, it may have a beneficial role in preventing COVID-19 infections. However, more research is needed to confirm this.

        This product also contains 60 percent of the daily value of zinc, which has been shown to play a role in several different immune functions. Zinc deficiency has been linked to a weakened immune system.

        Finally, it contains 25 milligrams of black elderberry fruit extract. A review published in 2021 found that elderberry may be beneficial for treating viral respiratory illness; however, the authors acknowledge that more research is needed to draw firm conclusions.

        Since it contains honey, it’s not suitable for children under 2 years old. In rare cases, honey can cause infant botulism, due to intestinal colonization of Clostridium botulinum, which may be present in honey. Symptoms of infant botulism include constipation, trouble feeding, and hypotonia (where your baby may feel unusually limp when held) and progress to generalized weakness, slow reflexes, and respiratory distress.

        If a child under 2 is experiencing a cough, Ott recommends nonpharmacological options like using a humidifier and a vapor rub.
        robitussin nighttime cough syrup in blue raspberry.

        Best for Nighttime Relief

        Robitussin Maximum Strength Nighttime Cough DM

        Pros

        • Contains dextromethorphan and antihistamine
        • Contains soothing menthol
        • Multi-symptom relief
        • Alcohol-free

          Cons

          • May increase risk of urinary retention, morning grogginess
          • Not recommended for those taking MAOIs
          • Not suitable for children under 12

          Buttarazzi generally recommends choosing nondrowsy cough syrups like the ones listed above, even at night, because the nighttime syrups typically rely on sedating antihistamines. However, if coughing is truly keeping you from sleeping, she recommends Robitussin Maximum Strength Nighttime Cough DM, noting that it only contains a low dose of antihistamine (plus dextromethorphan to help suppress a cough).

          Because this cough syrup contains both a cough suppressant and an antihistamine, it can relieve a variety of symptoms, including cough, runny nose, sneezing, itchy or watery eyes, and an itchy nose or throat, making it a good choice for people who are experiencing multiple symptoms related to allergies or the common cold. It’s also alcohol-free and contains menthol, which can soothe irritation and make it feel easier to breathe.

          “It may leave you groggy in the morning,” cautions Buttarazzi, “and can increase the risk of urinary retention, especially in older adults.” Urinary retention means you can’t fully empty your bladder, even when you feel the urge to urinate, and is a side effect of the antihistamine doxylamine.


          Goodsense cough syrup

          Best Nondrowsy Formula

          GoodSense 12 Hour Cough DM

          Pros

          • Nondrowsy
          • Only one active ingredient
          • Affordable
          • Relieves cough for up to 12 hours
          • Alcohol-free

          Cons

          • Contains sodium metabisulfite
          • Doesn’t relieve congestion or mucus
          • Not recommended for those taking MAOIs

          If you’re looking for a nondrowsy cough syrup, GoodSense 12 Hour Cough DM is an affordable option. It contains just one ingredient — dextromethorphan polistirex extended release — which Buttarazzi says shouldn’t cause drowsiness in most people.

          The time-release form of dextromethorphan provides relief for up to 12 hours. Plus, because it only contains dextromethorphan, it can be used in children ages 4 and older; most other cough syrups that contain an expectorant are not appropriate for children under 12 years.

          However, because it doesn’t contain an expectorant, it may not be the best choice for individuals with a wet cough or congestion caused by excessive mucus. It also contains sugar, which some people may want to avoid. And it contains sodium metabisulfite, which may trigger allergic-type reactions in people with a sulfite sensitivity.

          Comparison Table

          Best For
          Active Ingredients
          Flavor
          Dosage
          Wet coughs

          Dextromethorphan HBr, guaifenesin
          Honey and berry, berry
          Children 12 and older: 20 mL; Adults: 20 mL
          Allergies
          Diphenhydramine HCl

          Wild cherry
          Children 6–11: 5–10 mL; Children 12 and older: 10–20 mL; Adults: 10–20 mL
          Adults
          Dextromethorphan HBr, guaifenesin


          Honey
          Children 12 and older: 20 mL; Adults: 20 mL
          Multi-symptom
          Dextromethorphan HBr, guaifenesin
          Raspberry

          Children 12 and older: 20 mL; Adults: 20 mL

          Travel
          Dextromethorphan polistirex extended release


          Orange, grape
          Children 4–6: 2.5 mL; Children 6–12: 5 mL; Children 12 and older: 10 mL; Adults: 10 mL
          Young kids
          Dark honey, vitamin D, zinc, elderberry fruit extract
          Mixed berry
          Children 2 and older: 5 mL
          Nighttime relief

          Dextromethorphan HBr, doxylamine succinate
          Wildberry
          Children 12 and older: 20 mL every 6 hours; Adults: 20 mL every 6 hours
          Nondrowsy formula
          Dextromethorphan polistirex extended release
          Orange
          Children 4–6: 2.5 mL; Children 6–12: 5 mL; Children 12 and older: 10 mL; Adults: 10 mL

          How We Chose the Best OTC Cough Syrups

          You deserve recommendations you can trust, which is why we compiled this list using a clear, evidence-informed process. To ensure accuracy and safety, we consulted three board-certified physicians:

          • Allie Buttarazzi, MD, a diplomate of the American Board of Lifestyle Medicine and double board-certified physician who is co-owner of Maine Street Medical in Brunswick
          • Heather Gosnell, MD, a board-certified pediatrician in Phoenix
          • Chrissie Ott, MD, a triple board-certified physician in Portland, Oregon

          Their insights helped us evaluate how different OTC cough syrups work and which ones are most appropriate for different individuals and situations. We considered factors like active ingredients, alcohol and sugar content, dosage and frequency, flavor, age range, and price. By weighing these criteria with input from our experts, we identified the OTC cough syrups most likely to provide safe and effective relief for a range of different types of cough.

          What to Look for When Buying OTC Cough Syrups

          Not all cough syrups work the same way, so it’s important to choose one that’s designed to treat the symptoms you’re experiencing. Here are some factors to keep in mind when shopping for OTC cough syrups:

          • Active Ingredients Look for expectorants (like guaifenesin) if you have a wet cough and need to loosen mucus, suppressants (like dextromethorphan) if you have a dry, hacking cough, or antihistamines (like diphenhydramine) if your cough is related to allergies.
          • Age Range Many cough syrups aren’t safe for young children, so it’s important to choose products that are designed for the age range of the person taking the medication.
          • Dosage and Frequency Determine how often you’ll need to take it, and ensure that it aligns with your schedule. Some cough syrups contain timed-release ingredients, which may be more convenient, as you won’t need to take the medicine as often.
          • Alcohol or Sugar Content People with diabetes, children, or those avoiding alcohol may need to avoid cough syrups with these ingredients.

          FAQ

          What’s the difference between cough suppressants and expectorants?

          A cough suppressant (like dextromethorphan) helps reduce the frequency and severity of a cough, and it can be useful when you have a persistent, dry cough. An expectorant (like guaifenesin) helps thin mucus, making it easier to clear. This makes it a good choice if you have a wet, productive cough but are struggling to clear the mucus.

          “I tell my patients to look for dextromethorphan if they need a suppressant, and guaifenesin if they need an expectorant,” says Buttarazzi. As for ingredients to avoid, “I generally recommend skipping products with a decongestant like phenylephrine, since it isn’t very effective,” she adds.

          Buttarazzi also recommends avoiding antihistamines like doxylamine or diphenhydramine, unless absolutely necessary, as they can make you drowsy. Finally, “I also steer patients away from combination syrups that contain acetaminophen,” she explains, “and if you do need it, it’s best to take it separately, so you can control the dose.”

          “OTC cough syrups are unsafe for children under 4,” says Dr. Gosnell, “and not recommended under 6, as studies show no benefit in younger kids.” She adds that these medications can cause harmful side effects in children, including a faster heart rate, restlessness, confusion, and sleepiness.

          “For children over 6, dextromethorphan may be used,” explains Gosnell, “but honey is equally effective and safer for children older than 1 year.” (Honey should never be given to infants under 1 year, due to the risk of botulism.)

          When choosing a cough syrup for children, Ott recommends selecting single-ingredient cough syrups whenever possible to avoid overdosing on other ingredients, such as antihistamines and decongestants.

          “Studies show that honey helps reduce cough in children over 1 year old,” says Gosnell, “outperforming decongestants and antihistamines, which are no better than placebo.” She adds that vapor rub has also been shown to help by reducing cough and congestion and improving sleep.

          For most people, there aren’t many downsides to taking OTC cough syrups, says Buttarazzi. However, some people may notice mild drowsiness from dextromethorphan and added antihistamines, so try your first dose when you don’t need to drive or work, she adds. 

          You can usually take cough syrup if you’re on other medications, but Buttarazzi recommends double-checking with your doctor or pharmacist to rule out any interactions that are specific to your prescriptions. For example, dextromethorphan may interact with MAOIs.


          “Nighttime cough syrups have not been shown to improve sleep in children,” says Gosnell. For adults, Buttarazzi generally recommends nondrowsy options, unless they are absolutely necessary, as many nighttime syrups rely on sedating antihistamines that can leave you groggy in the morning and may increase the risk of urinary retention, especially in older adults.

          If you choose to use cough syrups in your children, Gosnell recommends sugar-free and alcohol-free versions. “Sugar offers no symptom relief and can cause tooth decay and provide excess calories,” she explains, “while alcohol also provides no benefit and may cause central nervous system depression, low blood sugar, and accidental overdose.”

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